RECOVER Clinical Trials
Together, we can explore options that may help improve Long COVID symptoms
RECOVER clinical trials are designed as platform protocols that allow researchers to study multiple interventions, or possible treatments, at the same time. Enrollment for these trials will be local and site-based, which means clinical research sites across the United States will identify and contact potential participants from their health systems and surrounding communities. RECOVER’s 8 phase 2 clinical trials will explore 13 possible treatments for these Long COVID symptoms:
Autonomic Dysfunction
Dizziness, fast heart rate, shortness of breath, upset stomach, or other changes in body functions that happen automatically
Cognitive Dysfunction
Brain fog, trouble thinking clearly, memory changes, slowed attention, and other symptoms related to brain function
Exercise Intolerance and Fatigue
Exhaustion or low energy that interferes with daily activities
Sleep Disturbances
Changes in sleep patterns or ability to sleep
Viral Persistence
When the virus that causes COVID-19 stays in the body and causes damage to organs or the immune system to not function properly
Learn more about why we are studying these focus areas
After the studies are complete and the data have been analyzed, the overall study results will be shared widely with the public and in academic publications.
What is Long COVID?
Long COVID is a chronic health condition that occurs after a COVID-19 infection and lasts for at least 3 months. The long-term effects of COVID may be different for everyone and can affect many different parts of the body, such as the brain, heart, and lungs.
Who is leading the clinical trials?
The RECOVER team includes Patient, Caregiver, and Community Representatives, doctors, and researchers from across the country. Community partners from many different backgrounds help make sure RECOVER research includes and benefits communities that are most affected by Long COVID.
Who can enroll?
The RECOVER clinical trials are phase 2 clinical trials, which test the safety and effectiveness of
treatments typically in groups of 100-300 participants. A total of around 3,300 adults will be enrolled across 8 clinical trials. The number of participants in each clinical trial ranges from 180 up to 900.
Each clinical trial has specific guidelines for who can enroll to make sure the study is a good fit for each participant. Enrollment will take place at clinical research sites located throughout the United States. A track record for enrolling diverse participants was a key criterion for site selection. Sites will contact potential participants in their local communities to enroll in the clinical trials.
If you are interested in taking part in a RECOVER clinical trial, email RECOVERresearch@duke.edu.
Where are the sites located?
Sites are listed in the study records on clinicaltrials.gov as they begin enrolling participants. Sites are selected based on their closeness to communities that are most affected by Long COVID, as well as their:
- expertise in the symptom area and the possible treatment being studied
- access to facilities and equipment needed to successfully run the study
- connections with health organizations and community leaders
- experience enrolling diverse groups of participants
Design of the
Clinical Trials
Clinical Trials
Each site in a RECOVER clinical trial follows the same study plan, or protocol, so we can combine the data from many locations.
This helps us get answers for more people faster.
Want updates on the clinical trials?
Sign up for the RECOVER Report to get emails with the latest information about all RECOVER research, including the clinical trials.