Design of the Clinical Trials
The RECOVER Initiative’s 8 clinical trials are exploring 13 study interventions, or possible treatments, for post-acute sequelae of SARS-CoV-2 infection (PASC), known as Long COVID.

Study interventions include study drugs, medical devices, and other approaches. Some study interventions are repurposed drugs—medicines approved by the U.S. Food and Drug Administration (FDA) to treat health conditions that are not related to Long COVID. Each of the repurposed drugs in RECOVER clinical trials must be studied as a possible treatment for Long COVID symptoms before the FDA can approve the drug to be used as a treatment for this health condition.
There are 5 RECOVER platform protocols with one or more appendix, or clinical trial, within the platform. The protocol for each platform describes the goals of the research, criteria for enrolling participants, possible treatments, study activities, and more. Clinical trial sites are listed in the clinicaltrials.gov study records, linked below. Study sites will contact potential participants in their local communities.
PASC Cognitive Recovery (PASC-CoRE) is an online goal management training program.
Transcranial Direct Current Stimulation (tDCS) is a safe, noninvasive form of brain stimulation.
This page will be updated regularly as the clinical trials progress. Sign up for the RECOVER Report to get monthly emails with the latest information about all RECOVER research, including clinical trials.